Standardization of Cinnamomum species using analytical techniques

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Ramanarain Ruia College,

The reliance on therapeutic values, described in ancient texts and current interpretations by specialists in the field of Ayurveda, research in several countries has been initiated scientifically to determine the efficacy of better known medicinal plants in modern therapeutic methods. For the standardization of plants, we have undertaken detail phytochemical investigation of an important medicinal plant Cinnamomum species. Cinnamomum tamala and Cinnamomum zeylanicum belongs to family Lauraceae. It has been well known in herbal and oriental medicines due to its various activities, such as bladder disorders, diarrhea, nausea and spermatorhea. It has hypoglycemic and hypolipedimic properties. In the present work, extraction with aqueous and non-aqueous solvents, testing for toxicity and anti-diabetic activity of plant material have been undertaken. The plant material was authenticated, powdered and standardised. The extracts were standardized by using chemical and chromatographic methods such as HPTLC and HPLC. Heavy metals analysis using ICP-AES technique was also carried out to ensure the safety of the pant material.

In standardization of the herbal drugs, it is necessary to determine whether the drug produces biological effect and hence its effect on suitable animal models is studied. The acute toxicity study was carried out on rats as model. The efficacy of the plant material was determined out by administering the plant material to the alloxan induced rats. It was compared with decrease in blood sugar level obtained by administration of the antidiabetic drug glibenclamide.