Efficacy Of A Polyherbal Combination In Treatment Of Kidney Dysfunction In Rats

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EFFICACY OF A POLYHERBAL COMBINATION IN TREATMENT OF KIDNEY DYSFUNCTION IN RATS
Sarfare S, Menon S.N and Sunita Shailajan
S.P. Mandali s Ramnarain Ruia College
Matunga, Mumbai - 400019.

Several plants have been reported in Ayurvedic literature for treatment of kidney diseases. Most of these plants, however, have not been evaluated for their efficacy and their desired pharmacological effect. The present study evaluates the use of a combination of Zea mays, Hordeum vulgare, Moringa oleifera and Mimosa pudica for treatment of drug induced kidney damage in Albino Wistar rats. The animals were
randomly divided into four groups of six animals each viz; Normal control, Gentamicinncontrol, Natural recovery and Polyherbal treatment group. Kidney damage was induced by an intra-peritoneal injection of Gentamicin sulphate at a concentration of 80 mg/kg/day for 8 days. The treatment group was orally administered 0.5 g/kg/day of combination of Zea mays, Hordeum vulgare, Moringa oleifera and Mimosa pudica in distilled water for 8 days. The other groups were orally administered distilled water as a sham treatment. The assessment of renal damage was done by blood and tissue biochemical parameters and histopathology. The results show that treatment with aqueous slurry of polyherbal combination causes reduction in the levels of ALT, AST, BUN and Creatinine in plasma and show elevated levels of proteins as compared to natural recovery group. Elevated levels of nucleic acid and proteins in kidney indicate tissue rejuvenation in the treated animals. Histopathological evidence supports the recovery of kidney after damage in the animals treated with polyherbal combination. The polyherbal combination therefore, shows potential to be used as adjunct therapy with nephrotoxic therapeutic drugs. Key words: - Zea mays, Hordeum vulgare, Moringa oleifera, Mimosa pudica, Gentamicin.